Molecular clockwork
CLOCK, BMAL1, PER, CRY and associated loops generate self-sustaining cellular rhythms.
ExploreChronobiology is the study of biological rhythms and the timing systems that coordinate physiology and behavior.
Chronobiology is the study of biological rhythms and the timing systems that coordinate physiology and behavior.
The circadian system is not one clock in the brain; it is a network of central and peripheral oscillators influenced by environmental and behavioral cues.
ChronoSense® connects the biological hypothesis to delivery, evidence, data and a controlled route to market.
CLOCK, BMAL1, PER, CRY and associated loops generate self-sustaining cellular rhythms.
ExploreThe suprachiasmatic nucleus responds strongly to light and helps organize whole-body timing.
Liver, muscle, gut, skin and other tissues have local oscillators influenced by feeding, activity and hormones.
The strength of a rhythm can matter independently of its phase or timing.
ExploreInternal clocks and external routines can become mismatched.
ExploreRepeated signals are needed to characterize a rhythm; a single value rarely describes timing.
ExploreThe platform is designed to move through explicit stages, with evidence and access appropriate to each one.
Light, food, activity and temperature provide timing cues.
Molecular feedback loops create approximately 24-hour cycles.
Neural, hormonal and metabolic signals connect clocks across tissues.
The system adjusts to changing schedules, environment and life stage—with limits.
Continue into rhythm amplitude, disruption and multi-system coordination.